Devlog 7: Since Devlog 6, I’ve made a lot of progress in expanding FoldCheck’s biological information and making the Region Explorer much more detailed. I started by integrating more data from UniProt, allowing users to explore annotated functional regions of a protein, including their names, residue positions, lengths and biological roles. One major addition was the ability to investigate protein interactions, where FoldCheck retrieves information about interaction partners, their functions, UniProt accessions and available experimental evidence. I also added supporting research references, including PubMed publications, and developed a system that connects biological findings to the protein being explored. A challenge I faced was making this information work dynamically across different proteins, rather than hardcoding information specifically for p53. I also had to fix several issues involving matching interaction partners, retrieving the correct biological information and preventing empty or repetitive sections from appearing. FoldCheck can now provide much more detailed explanations of functional regions and protein interactions, helping users understand not just the 3D structure, but also the biological evidence behind it. Next, I’m working on a dedicated PAE analysis page to help users investigate uncertainty in the relative positions of different parts of a protein! I know I said PAE last time but I got distracted.. MB!